Genomic plasticity and rapid host switching promote the evolution of 1 generalism in the zoonotic pathogen
نویسندگان
چکیده
منابع مشابه
Role of evolved host breadth in the initial emergence of an RNA virus.
Understanding how evolution promotes pathogen emergence would aid disease management, and prediction of future host shifts. Increased pathogen infectiousness of different hosts may occur through direct selection, or fortuitously via indirect selection. However, it is unclear which type of selection tends to produce host breadth promoting pathogen emergence. We predicted that direct selection fo...
متن کاملSpecialization and generalization in the diversification of phytophagous insects: tests of the musical chairs and oscillation hypotheses.
Evolutionary biologists have often assumed that ecological generalism comes at the expense of less intense exploitation of specific resources and that this trade-off will promote the evolution of ecologically specialized daughter species. Using a phylogenetic comparative approach with butterflies as a model system, we test hypotheses that incorporate changes in niche breadth and location into e...
متن کاملFluctuating temperature leads to evolution of thermal generalism and preadaptation to novel environments.
Environmental fluctuations can select for generalism, which is also hypothesized to increase organisms' ability to invade novel environments. Here, we show that across a range of temperatures, opportunistic bacterial pathogen Serratia marcescens that evolved in fluctuating temperature (daily variation between 24°C and 38°C, mean 31°C) outperforms the strains that evolved in constant temperature...
متن کاملHow transposons drive evolution of virulence in a fungal pathogen
2 2 Genomic plasticity enables adaptation to changing environments, which is especially relevant 2 3 for pathogens that engage in arms races with their hosts. In many pathogens, genes 2 4 mediating aggressiveness cluster in highly variable, transposon-rich, physically distinct 2 5 genomic compartments. However, understanding of the evolution of these compartments, 2 6 and the role of transposon...
متن کاملCooperative secretions facilitate host range expansion in bacteria
The majority of emergent human pathogens are zoonotic in origin, that is, they can transmit to humans from other animals. Understanding the factors underlying the evolution of pathogen host range is therefore of critical importance in protecting human health. There are two main evolutionary routes to generalism: organisms can tolerate multiple environments or they can modify their environments ...
متن کامل